Cob(II)yrinic acid a,c-diamide reductase
Appearance
cob(II)yrinic acid a,c-diamide reductase | |||||||||
---|---|---|---|---|---|---|---|---|---|
Identifiers | |||||||||
EC no. | 1.16.8.1 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
|
In enzymology, a cob(II)yrinic acid a,c-diamide reductase (EC 1.16.8.1) is an enzyme that catalyzes the chemical reaction
![](http://upload.wikimedia.org/wikipedia/commons/thumb/f/f4/Cob%28II%29yrinic_acid_a%2Cc-diamide_reductase.svg/480px-Cob%28II%29yrinic_acid_a%2Cc-diamide_reductase.svg.png)
2 cob(I)yrinic acid a,c-diamide + FMN + 3 H+ 2 cob(II)yrinic acid a,c-diamide + FMNH2
The three substrates of this enzyme are cob(I)yrinic acid a,c-diamide, flavin mononucleotide, and H+; its two products are cob(II)yrinic acid a,c-diamide and FMNH2.
Classification
[edit]This enzyme belongs to the family of oxidoreductases, specifically those oxidizing metal ion with a flavin as acceptor.
Nomenclature
[edit]The systematic name of this enzyme class is cob(I)yrinic acid-a,c-diamide:FMN oxidoreductase. This enzyme is also called CobR and cob(II)yrinic acid-a,c-diamide:FMN oxidoreductase (incorrect).
Biological role
[edit]This enzyme is part of the biosynthetic pathway to cobalamin (vitamin B12) in bacteria.
See also
[edit]References
[edit]- Blanche F, Maton L, Debussche L, Thibaut D (1992). "Purification and characterization of Cob(II)yrinic acid a,c-diamide reductase from Pseudomonas denitrificans". J. Bacteriol. 174 (22): 7452–4. PMC 207442. PMID 1429467.
- Warren MJ, Raux E, Schubert HL, Escalante-Semerena JC (2002). "The biosynthesis of adenosylcobalamin (vitamin B12)". Nat. Prod. Rep. 19 (4): 390–412. doi:10.1039/b108967f. PMID 12195810.